作者：Wenjiao Liu1,2,3， Ting Gong1,2,3* ，Fangxiong Shi4 ，Houqiang Xu1,2,3 ，Xiang Chen1,2,3
期刊：Frontiers in Cell and Developmental Biology（IF=5.5，中科院2区）
发表年份：2022
摘要：For the male genetic materials to reach and fertilize the egg, spermatozoa must contend with numerous environmental changes in a complex and highly sophisticated process from generation in the testis, and maturation in the epididymis to capacitation and fertilization. Taste is an ancient chemical sense that has an essential role in the animal’s response to carbohydrates in the external environment and is involved in the body’s energy perception. In recent years, numerous studies have confirmed that taste signaling factors (taste receptor families 1, 2 and their downstream molecules, Gα and PLCβ2) are distributed in testes and epididymis tissues outside the oral cavity. Their functions are directly linked to spermatogenesis, maturation, and fertilization, which are potential targets for regulating male reproduction. However, the specific signaling mechanisms of the taste receptors during these processes remain unknown. Herein, we review published literature and experimental results from our group to establish the underlying signaling mechanism in which the taste receptor factors influence testosterone synthesis in the male reproduction.